General Electric Master thesis (30hp) in Molecular Biology/BioChemistry in Uppsala, Sweden
Role Summary:GE Healthcare Life Sciences work with a wide range of products for both lab- and bioprocess scale. “mAb applications” is a section within the Downstream Bioprocessing Department (90 people) which belong to the Global BioProcess R&D (500 people). The section is based in Uppsala and consists of 15 highly skilled research engineers and scientists all with an solid background in bioanalysis and downstream purification.
Essential Responsibilities:The section is responsible for designing downstream processes for monoclonal antibodies and related molecules and is also contributing to the development of new resins based on structure function relationships.
The Master thesis work will be in the field of molecular biology / biochemistry exploring the VH3-interaction to Protein A.
The diploma work will include cloning, expression and purification of different VH3 sequences but also characterization of the binding strength by Biacore and/or column experiments. All expressed proteins will be analyzed by size exclusion chromatography, LC-MS and capillary electrophoresis. Binding verification experiments will be performed at relevant loads for industrial bioprocesses. The experimental work will be documented in an electronic notebook and results will be presented on a regular basis to supervisor and the project group.
Master thesis work will be for spring 2020: 15 January to 15 June. Deadline for application is 1 December 2019. For questions, please contact Eva Heldin: tel. +46 70 650 03 91 or email@example.com.
Master student within molecular biology /biotechnology / biochemistry
Knowledge in cloning and expression systems
Knowledge in chromatographic techniques and relevant methods for analysis of proteins
Good interpersonal skills
A structured way of working
Ability to work independently, alone as well as with others
Good skills in English
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